Advances in blockchain technology offer a decentralized ledger with transformative potential for healthcare data management, facilitating secure transactions and transparent record-keeping. Nevertheless, the sensitive nature of patient data requires enhanced privacy measures. This paper introduces a comprehensive framework enabling researchers to conduct collaborative statistical analysis on health records while preserving privacy and ensuring security. Statistics are invaluable across various disciplines, guiding consequential decisions based on such analysis. The framework integrates privacy-preserving techniques, including secret-sharing, secure multiparty computation (SMPC), and homomorphic encryption, within a blockchain-based healthcare ecosystem. Patient data is divided using secret-sharing, enabling controlled access. Furthermore, SMPC allows secure data aggregation without revealing individual records, while homomorphic encryption supports computation on encrypted data within smart contracts. Through a series of controlled experiments, we assess the framework’s effectiveness in maintaining data privacy, facilitating secure collaboration, and conducting statistical data analysis. The results demonstrate successful preservation of data privacy and secure analysis on a permissioned blockchain using the Hyperledger Fabric platform. Our framework showcases efficient performance while effectively utilizing system resources. This research contributes to the evolution of secure and privacy-conscious healthcare data analysis, paving the way for practical applications and future advancements.