Background: Psoriasis (PsO) is classified as a systemic inflammatory condition with psychiatric, metabolic, arthritic,
and cardiovascular complications. Several chronic inflammatory disorders have been linked to elevated Toll-like
receptor (TLR) expression, activity, and ligands.
Purpose: The study aimed to evaluate TLR 5 and TLR 8 genes expression in psoriasis patients and their correlation to
the activity of the disease.
Patients and methods: This case-control study was conducted from January 2023 to January 2025 on 46 participants,
including 23 cases with PsO and 23 healthy control age- and sex-matched subjects. Evaluation of genes expression of
TLR 5 and TLR 8 was performed by real-time PCR.
Results: The TLR5 expression among the patients was considerably less than the controls, in contrast to TLR8
expression, which was markedly higher (p