Background: Laparoscopic surgery (LC) is a surgical method that has many advantages since it involves smaller incisions with less bleeding and ileus in the postoperative period and provides faster recovery and reduced hospital stay. This study aimed to compare between the effectiveness of Erector spinae plane block (ESPB) and Oblique subcostal transversus abdominis plane block (OSTAPB) under ultrasound guidance. Methods: This prospective randomized study was conducted on 60 patients with American Society of Anaesthesiology (ASA) physical status I-III, Between the ages of 18-60 years who were presented with patients scheduled for elective LC surgery, presented to Benha university hospital. Patients were equally randomized into two groups: group 1 (ESPB): 30 patients received ultrasound guided ESP block and group 2 (OSTAPB): 30 patients received ultrasound guided OSTAP block