Endometrial carcinoma is the most common invasive neoplasm of the female
reproductive tract. L1 cell adhesion molecule (L1CAM), Sperm-associated antigen
9 (SPAG9), and P53 have a role in the process of tumorigenesis and progression
of several human malignant tumors, however, the role of them in cancer of
endometrium is still not clear.
Aim
The study was performed to evaluate L1CAM, SPAG9, and P53 expression
about different clinicopathological parameters in endometrial endometrioid
adenocarcinoma.
Methods
The immunohistochemical study was performed on 50 cases of endometrial lesions
including endometrial hyperplasia without atypia (10 cases), endometrial hyperplasia
with atypia (10 cases), and endometrial endometrioid carcinoma (30 cases).
Immunohistochemical staining techniques were used to evaluate the role of L1CAM,
P53, and SPAG9 in endometrial endometrioid adenocarcinoma (EEC) and their relation
to different clinicopathological data and patient’s survival followed for 36 months.
Results
This study declared that both L1CAM and SPAG9 were found to be upregulated in
EEC. Their over-expression was related to adverse clinicopathological parameters
including high tumor grade, deep myometrial invasion, lymphovascular Invasion
(LVI), and advanced tumor stage, while there was no significant relation
between their expression and tumor size, cervical affection, and lymph node
involvement. A high statistically significant link between L1CAM expression and
poor patient survival was detected. Mutant type P53 was significantly related to
adverse clinicopathological data as high tumor grade, deep myometrial invasion,
lymphovascular space invasion (LVSI), and high tumor stage. There was a positive
significant relation between mutant type P53 and high SPAG9.
Conclusions
The early identification of EEC in asymptomatic high-risk women may benefit from
L1CAM and SPAG9 testing in combination with P53 protein. Also, they could be
viewed as separate predictive variables in the EEC and might play a crucial part in
the EEC’s chemoresistance.