Background: Stroke is a complex condition influenced by various factors, with ischemic stroke (IS) having diverse
etiologies and pathogenic mechanisms. Emerging evidence suggests that its development involves an interplay between
genetic and environmental components. One notable genetic factor is the single-nucleotide polymorphism (SNP)
rs3918242 in the MMP-9 gene, which may heighten an individual's susceptibility to IS.
Objective: Toelucidate the potential association between the MMP-9 rs3918242 polymorphism and the risk of IS, while
also exploring the various clinical manifestations observed among the Egyptian IS patient cohort.
Materials and methods:The study recruited 70 IS patients from Benha University Hospitals, Egypt, along with 30
healthy controls. The MMP-9 gene variant (rs3918242) was analyzed using polymerase chain reaction (PCR) coupled
with restriction fragment length polymorphism (RFLP) employing the SphI restriction enzyme.
Results: A significant association of CT genotype (OR =3.22, 95% CI =1.68–6.18, P