Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammatory condition that often
requires surgical intervention. Despite advances in endoscopic sinus surgery (ESS), recurrence rates remain significant.
Platelet-rich plasma (PRP), known for its regenerative properties, has been suggested to reduce inflammation and promote healing.
Methodology This prospective randomized controlled clinical trial was carried out on 40 patients which aims
to evaluate the effectiveness of PRP in reducing the recurrence and healing of sinonasal polyps after functional endoscopic sinus surgery (FESS) after 6 months follow-up. Patients aged over 18 years and under 60 years old, with more
than 3 months of CRS symptoms with endoscopic evidence of polyps and/or mucosal changes on a CT scan were
included in our study. Previous sinus surgery, systemic vasculitis, immune deficiency, allergic fungal rhinosinusitis,
patients with uncontrolled systemic diseases or coagulopathy, history of asthma, aspirin sensitivity, cystic fibrosis,
and congenital mucociliary problems were excluded from our study.
Results Both groups showed improvement in Lund-Kennedy scores and SNOT-22 scores postoperatively. However, Group 1 demonstrated significantly greater improvement at 3 months (median Lund-Kennedy score: 4.0 vs.
6.0, p