Background: Human’s Coronavirus Disease 2019 (COVID-19) is a pandemic syndrome with many musculoskeletal manifestations besides respiratory, internal, neurological, and psychosocial symptoms. Physiotherapy can have a role in resolving these problems. Purpose: to review the literature about musculoskeletal symptoms in COVID-19 and rehabilitation. Besides, this study was to describe a 70-year-old male patient post-COVID-19, including the description of physical therapy interventions and their effects on various outcome measures such as oxygen saturation, heart rate, and function. Methods: A literature search on databases using keywords (exercises, rehabilitation, physical therapy, COVID-19, musculoskeletal) was done. As well, a 70-year-old male post-ICU patient was physically assessed and underwent physical therapy interventions. Results: COVID-19 had a significant negative impact on patients, musculoskeletal and general health. Several physiotherapeutic interventions were reported. Exercise significantly improved the disability of a 70-year-old male post-ICU patient. Conclusion: Musculoskeletal symptoms are prevalent among COVID-19 patients, which negatively affect function. Physical therapy, especially exercises, is crucial for the management of musculoskeletal symptoms and associated disability in post-COVID-19 patients.