ABSTRACT

Polycystic Ovary Syndrome (PCOS) is a commonly occurring condition, inuencing both metabolic and repro-ductive system-related functions. Hence, the objective of this research was to examine the possibility inuence of Cinnamomum zeylanicum (CZ) on hormonal disorders, hyperinsulinemia, inammation and some gene ex-pressions in rats with PCOS pathogenesis. 50 female albino rats were classied into ve groups: Control group: rats were received no medication. Induced PCOS Group: rats were treated daily with Letrozole at dose 1 mg/kg for 28 days. Metformin group: rats were given metformin at dose 150 mg/kg for 30 days after receiving Letro-zole. Cinnamomum zeylanicum group: rats received Letrozole like group II and treated for 30 days with 200 mg/kg of the hydroalcoholic extract of CZ. Metformin + CZ group: rats given daily metformin and hydroalcoholic extract of CZ for 30 days after Letrozole administration. PCOS Rats exhibited a marked elevation of serum testosterone and LH hormone with a marked decrease of FSH hormone. A signicant increase in insulin and glucose concentrations, augmented in TNF-α and IL-6 concentrations, upregulation of GSK-3β and miRNA-21 genes, and downregulation of SIRT-1 expression. Histopathological examination revealed multiple ovarian cysts with a notable absence of corpora lutea, increased stromal thickness, hyperplasia of the theca cells, and fol-licular arrest. Management of diseased rats with CZ extract showed noticeable improvement in all parameters. The ndings indicate that cinnamonaldehyde in Cinnamomum zeylanicum extract has benefcial effects on hormonal imbalance, insulin sensitivity, and inammation underscoring its potential as a treatment approach for PCOS.