Background
Psoriasis is a prevalent disorder of primarily skin and joint affection with a wellknown
genetic background and a sophisticated pathogenesis. The inducible nitric
oxide synthase (iNOS) gene polymorphisms are unexplored areas of research
when it comes to psoriasis.
Objectives
The aim of the study was to investigate the probable link between iNOS gene
polymorphisms (-954 G/C and Ex 16+14C/T) and susceptibility to psoriasis and
psoriatic arthritis (PsA).
Patients and methods
We included three groups of participants: 100 participants each of psoriasis, PsA
and healthy controls. Genetic polymorphism analysis was performed utilizing the
PCR with the restriction fragment length polymorphism method.
Results
Genetic analysis of iNOS polymorphism at Ex 16+14C/T revealed significantly
increased CT genotype frequency and significantly lower CC genotype frequency in
psoriasis (P=0.0011, 0.003, respectively) and PsA patients (P=0.001, P