Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder associated with both reproductive dysfunction and metabolic abnormalities. Emerging evidence links vitamin D deficiency with worsened PCOS manifestations, including insulin resistance and menstrual irregularity. However, few studies have compared these effects between lean and obese PCOS phenotypes.
Objective
To compare baseline serum vitamin D levels between lean and obese PCOS patients and evaluate the impact of vitamin D supplementation on metabolic and reproductive outcomes in both groups.
Methods
A prospective interventional study was conducted on 100 women with PCOS, aged 18–40, diagnosed according to Rotterdam criteria. Participants were divided into two groups: Group A (lean, BMI < 20 kg/m²) and Group B (obese, BMI ≥ 30 kg/m²). All participants received high-dose oral vitamin D …