Uterine leiomyoma represent over 75% of the amiable tumors in ladies of conceptive age amass. Endometrium is a hormonally responsive tissue . The reaction of endometrium to incitement by endogenous or exogenous steroid hormones is unsurprising Endogenous reaction is an impression of the hypothalamic–pituitary-ovarian pathway.
Aim of this study
to assess serum level of E2 and study endometrial histological changes in instances of fibroid uterus .
Patients and methods
This study included forty ladies have symptomatic fibroid uterus. history was taken, general examination, ultrasound examination, measuring serum estradiol and endometrial biopsy was taken by D&C or hysterectomy sent for histopathological examination.