Split air conditioning (AC) systems are the predominant choice for both commercial and residential applications. The primary refrigerant used in modern split AC systems is R410A, a hydrofluorocarbon (HFC) with a high global warming potential (GWP) of 2088. Additionally, due to its zeotropic nature, R410A cannot be recharged into a system with a leak, leading to increased maintenance costs. This research examines the feasibility of replacing R410A with R32 in split AC systems. R32 was selected due to its significantly lower GWP of 675 and higher latent heat of evaporation at a constant temperature. The study evaluates cooling capacity, energy consumption at different ambient temperatures, heating capacity, and the seasonal energy efficiency ratio (SEER) in the Egyptian market before and after retrofitting. The experimental process involved conceptualization, installation, data collection, and quantitative analysis. Results showed a 6% increase in cooling capacity at 35°C and a 9% increase at 43°C, with improved capacity retention at high ambient temperatures post-retrofit. Additionally, SEER improved by 15% after switching to R32. These findings confirm that converting an R410A-based system to R32 is both viable and effective.