Introduction: Athletes and youth consume energy drinks (Eds) more often. They are sold as supplements that increase both
mental and physical performance. Prolonged use of these increases the risk of cardiovascular disease.
Aim of the Work: The present work aimed to ascertain the extent of cardiac injury induced by EDs in mature male albino rats
and explore the possible cardioprotective impacts of Quercetin and Omega 3.
Materials and Methods: Forty adult albino rats were separated into 4 identical groups: the control group, the Omega 3
(Om) group, the Quercetin (Qu) group, and the Energy drink (ED) group. The ED group received Red Bull at a dose of 1.5
ml/100 g body weight , the Omega 3 group received both Red Bull and omega 3 at a dose of 300 mg/kg body weight ,while
Quercetin group received both Red Bull and Quercetin at a dose of 75 mg//kg body weight . For four weeks, each therapy was
administered by gastric gavage once a day. The goal of obtaining blood samples was to determine the level of cardiac enzymes.
Heart muscle samples were taken and prepared for histological and immunohistochemical examinations.
Results: The anti-oxidant enzyme activity, MDA level, and serum cardiac enzyme level were all significantly altered in
the ED treated group. The H&E stained sections revealed dark pyknotic nuclei in certain cardiomyocytes along with
aberrant architecture of the cardiac muscle fibers with broad endomysium between them. P53, Desmin, and anti-fibronectin
immunoreactivity were also shown to be disturbed. All of these results point to negative effects of EDs on the heart muscle
structure. Treatment with Omega 3 or quercetin improves the histopathological results and biochemical measures.
Conclusion: Since quercetin and omega 3 have anti-inflammatory, anti-oxidant, and anti-apoptotic qualities, they may be able
to lessen the potentially detrimental effects of energy drinks on the heart.