Background: Mastectomy women face many changes to their body in a more negative, ruminative way which may lead these women to criticize themselves and hence negatively affect not only their body-image, but also, their self-compassion. Aim of the study: This study aimed to evaluate the effect of acceptance and commitment training program on self-compassion and body-image among women with mastectomy. Resarch design: A quasi experimental design (one group pre and posttest) was utilized to achieve the aim of the study. Setting: The study was conducted at general surgery outpatient’s clinics at Benha University Hospital which is affiliated to Ministry of High Education, Benha city, Qalubia Governorate. Subject: A purposive sample of (60) women with mastectomy was utilized in this study. Tools: Three tools were used for data collection: Tool (1): - A- structured interviewing questionnaire sheet included socio demographic as well as clinical characteristics of the studied women. Tool (2):- Self-Compassion Scale (SCS) & Tool (3):- Body-Image Scale. Results: The result of the present study revealed that, more than half (55%) of the studied women had high level of self-compassion and more than half (56%) of the studied women had good level of body-image post-program implementation than before. Conclusion: Acceptance and commitment training program had a positive effect on self-compassion and body-image among the studied women with mastectomy. Recommendations: Generalization of acceptance and commitment training program for all women with mastectomy in all hospital to improve their self-compassion and hence their body-image.