Background
PRMT3 and IGF2BP1 overexpression has been detected in several malignancies
and has been recognized by their oncogenic role. No studies have handled the
expression of PRMT3 and IGF2BP1 in adrenocortical carcinoma (ACC) and
their association with outcome. This work aimed at exploring the significance
of PRMT3 and IGF2BP1 expression in ACC and their correlation with FOXM1
expression.
Patients and methods
Immunohistochemistry accessed quantitative expression of PRMT3, IGF2BP1,
and FOXM1 proteins in 60 cases of ACC and 20 cases of adrenocortical adenoma.
IGF2BP1 mRNA and PRMT3 mRNA were also evaluated using a quantitative realtime PCR.
Results
PRMT3, IGF2BP1, and FOXM1 expression were statistically highly significant in
ACC compared to adrenocortical adenoma (P