Background: Supplemental oxygen therapy (SOT) is a lifesaving drug when used appropriately
and cause harm if used inappropriately. Administering SOT has an essential role in preventing and
managing hypoxemia in both acute and chronic conditions. The aim of the study was to evaluate
the effect of nursing guidelines regarding safe and effective practices of supplemental oxygen
therapy among critically care patients. Research design: Quasi- Experimental research design (prepost test) was utilized to achieve the aim of the study. Setting: This study was conducted at
Intensive Care Unit (ICU) in Benha University Hospital. Sample: Convenient sample of ( ) nurse
from both sex who working in ICU during the time of data collection and agree to participate in this
study. Tools of data collection: Two tools were used, Tool I: Self-administered questionnaire
which consisted of two parts to assess A) Nurses' demographic data. B) Nurses' knowledge
questioners about safe and effective administration of supplemental oxygen therapy and Tool II:
Observational checklist for nurses' practice regarding safe and effective supplemental oxygen
therapy administration. Results: The study revealed that nurses' knowledge and practice regarding
safe and effective supplemental oxygen therapy administration pre guidelines implementation was
unsatisfactory level which improved post guidelines implementation, there was high significant
statistical positive correlation between nurses’ knowledge and their practice regarding safe and
effective administration of supplemental oxygen therapy at pre and post implementation of nursing
guidelines. Conclusion: Nursing guidelines effectively improved nurses' knowledge and practices
regarding safe and effective administration of supplemental oxygen therapy. Recommendation:
Ongoing educational and training guidelines for nurses are needed regarding safe and effective
administration of supplemental oxygen therapy and apply the guidelines on large sample selected
from intensive care unit at Benha University Hospital.