Background: Antibiotic abuse is a global public health concern, contributing to antimicrobial resistance and adverse health outcomes, older adult people who frequent consume antibiotic have limited awareness of risk associated with inappropriate use. The aim of this study was to assess awareness of older adult people regarding antibiotic abuse. Research design: Descriptive research design was utilized in this study. Setting: The study was conducted at Medical Outpatient Clinic affiliated to Benha University Hospital in Benha City. Sample: Simple random sample was used in this study. The total sample included 306 older adult people. Tools: Two tools were used I): A structured interviewing questionnaire which consisted of four parts to assess a): Demographic characteristics of the studied older adult people. B): Medical history of studied older adult people. C): Knowledge of older adult people about antibiotic abuse. D): Reported practices of older adult people regarding prevention of antibiotic abuse II): Was concerned with scale to assess attitude of older adult people about antibiotic abuse. Results: 45.1% of the studied older adult people were age ranged from 60 to less than 65 years old. 58.5% of them were female. 57.5% of them were lived in rural areas. 55.9% of the studied older adult people had poor total knowledge level about antibiotic abuse. 74.2% of the studied older adult people had unsatisfactory total reported practices level about prevention of antibiotic abuse. 61.1% of the studied older adult people had positive total attitude level about antibiotic abuse. Conclusion: There was a positive statistically significant correlation between the studied older adult people total knowledge score, total reported practices score and total attitude scores. Recommendations: Developing and implementing health educational program for older adult people in different health care setting to increase their awareness about antibiotic abuse.