Background Meningitis is an acute inflammation of the pia, arachnoids, and the fluid in the subarachnoid space of the
brain. Because there is no diagnostic biomarker, it is difficult to diagnose. Objective: The aim of the current study
was to evaluate the validity of using cerebrospinal fluid (CSF) Vitamin-D Binding Protein (VDBP) as a new potential
marker for diagnosing meningitis. Patients and methods: A cross-section study was conducted on 48 patients with
manifestations suggesting an acute meningitis, 28 patients with an acute meningitis who were divided into bacterial
group containing 10 patients and viral group containing 18 patients confirmed by laboratory investigations and 20
patients who were clinically suspected as an acute meningitis, but excluded by laboratory investigations, the study was
conducted within the period from May 2022 to December 2022. CSF and blood samples were obtained in pairs. CSF
and serum VDBP were measured in the 3 groups. CSF VDBP concentrations were compared versus serum VDBP
concentrations according to disease (viral meningitis vs. bacterial meningitis vs non-meningitis). Receiver operating
characteristic (ROC) analysis for diagnosing meningitis using CSF VDBP concentration was performed. Results:
There was a statistical significant difference as regard the CSF VDBP (P