Background: A virtual simulation (VS) is an innovative approach to providing virtual clinical experiences through a digital platform where learners can complete specific tasks in various potential environments. The aim of the study was to evaluate the effect of training virtual simulation skill on improving learning outcomes among nursing students. Research design: Experimental research design was used. Setting: This study was carried out at Medical Surgical Nursing Labs and Virtual Lab Faculty of nursing- Benha University. Sample: A systematic random sample of 229 medical surgical nursing students in first year second semesters throughout the 2023–2024 academic year. Classified into two groups; traditional group and virtual simulation (VS) group. Tools of data collection: three tools were used I: Structure students' questionnaire to assess knowledge about nasogastric tube insertion& virtual simulation, II: observational checklist to assess practice related to nasogastric tube insertion and III: Students' class satisfaction measuring questionnaire. Results: The study revealed that 16.5%and 92.2% of the studied nursing students of traditional and VS groups had good level of total knowledge about nasogastric tube insertion and virtual simulation post month(follow up), respectively. While 81.6%and 62.1 of the studied nursing students of traditional and VS groups had competent level of total practice about nasogastric tube insertion at follow up. Also, the study revealed that79.6% and64.1% of the studied nursing students of traditional and VS groups had high satisfaction level at follow up of training, Conclusion: virtual simulation skill showed its effectiveness in improving nursing students’ knowledge, practice and satisfaction. Recommendation: incorporating virtual simulation an effective teaching strategy, with traditional teaching in different nursing clinical courses to enhance nursing students’ performance in clinical settings.