Background: The tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential hepato-renal and anti-diabetic properties. In many countries, it is used as food and in some countries as therapeutics for the control and treatment of T2D. Objective: To investigate hepatorenal protective effect of dandelion and its role in improving exercise capacity in type 2 diabetic albino rats and its possible underlying mechanisms. Materials and methods: Induction of partial diabetes in 30 rats by STZ followed by biochemical investigation of C- peptide and blood glucose level with several kidney and liver parameters. In addition to non-enzymatic and enzymatic anti-oxidants in vitro were evaluated. Also, the pro-inflammatory mediators and the expression levels of pro-oxidants/pro-inflammatory and anti-inflammatory mediators using qPCR.