Hepatocellular carcinoma (HCC) is a highly prevalent form of liver cancer that necessitates accurate prediction models for early diagnosis and effective treatment. Machine learning algorithms have demonstrated promising results in various medical domains, including cancer prediction. In this study, we propose a comprehensive approach for HCC prediction by comparing the performance of different machine learning algorithms before and after applying feature reduction methods. We employ popular feature reduction techniques, such as weighting features, hidden features correlation, feature selection, and optimized selection, to extract a reduced feature subset that captures the most relevant information related to HCC. Subsequently, we apply multiple algorithms, including Naive Bayes, support vector machines (SVM), Neural Networks, Decision Tree, and K nearest neighbors (KNN), to both the original high