Background: Rheumatoid arthritis (RA) is a chronic autoimmune
disease that is associated with many auto-antibodies such as
rheumatoid factor (RF), Antiperinuclear factor (APF) , anticitrullinated
peptides and antikeratin antibodies (AKA).
Objectives:This study aimed to measure the serum level of antimutated
citrullinated vimentin antibodies(anti-MCV) and detection of
AKA in serum of RA patients.Also,for comparison between the results
of anti-MCV and AKA in diagnosis of early RA and their correlation
with disease activity. Methodology: This study included 30 patients
with RA ,30 patients with other rheumatic diseases and 30 matching
healthy controls. Patient’s assessment measures involved the disease
activity score (DAS-28) and visual analogue scale (VAS) . serum
samples were collected from patients and controls for measurement of
anti-MCV and detection of AKA using enzyme linked immunosorbant
assay (ELISA) and indirect immunofluorescent (IIF)) technique
respectively. Results: anti-MCV and AKA were significantly higher in
patients compared to controls (p