Background: Intraventricular hemorrhage (IVH) is a major neurological complication responsible
for preterm neonates' morbidity and mortality. In the first 72 hours of life, nurses have a critical role
in maintaining bundled practices for intraventricular hemorrhage prevention. The study aimed to
assess preventive care bundle guidelines for nurses on the incidence of intraventricular hemorrhage
among preterm neonates who were mechanically ventilated. This study was carried out at
Neonatal Intensive Care Unit of Specialized Pediatric Hospital at Benha city. Sample of the study
was convenient sample for nurses and purposive sample for preterm neonates who consisted of 60
preterm neonates on mechanical ventilation and 60 nurses who cared for them at previous setting.
Tools of data collection included four tools, (1) A structured Interviewing Questionnaire Sheet, (2)
Medical record of preterm neonates, (3) Intraventricular hemorrhage grading scale, (4) preventive
care bundle checklist. The main results of this study revealed high statistical significant
improvement in the studied nursesʹ total level of knowledge and total practice post- preventive care
bundle guidelines implementation. Additionally, there was a negative correlation between total
nurses' knowledge, their practice and IVH incidence pre and post-neonatal care bundle guidelines
implementation. The main recommendation is Conducting an orientation programs for nurses in
NICU with regular updates of knowledge and practice regarding preventing intraventricular
hemorrhage for enhancing the quality of care and reducing in the incidence of all grades of IVH.