AND AIM OF WORK
I
Muscle relaxants made genefal anaesthesla more easy and effective, facilitated surgery and redued post-operative morbidity and m~rtality. Th~ir universal rola in control led ventilation has contributed to the remarkable improvement in the management and prognosis of diseases associated with respiratory failure, e.g. convulsions { tetanus, status epilepticus }, drug over dosage, head, chest injuries, and in the intensive care units.
The ideal muscle relaxants should have the following properties:-(K~ and GL~, 1971)
1It
should
be
competitive
and
non-depolarizing,
thus
side
effects associated with
depolarizers
should
not
occur.
2The
cessation of the
neuromuscular
blorkade
should
not
depend
on
renal
or
hepatic
function,
so
diseases
of
one
or
both
of them
do
not
impair
its elimination.
3The
breakdown
products
should
not
posses
neuromuscular.
blocking effects
or
other
side effects.
~Relative
rapid
onset
and
short duration of
action.
5Non
cummulative
effects,
so
when
a
large
duration
is
desired,
repeated
or
continous
administration
can
be
done.