Background: Infertility is a significant stressor for couples, impacting women’s coping
way, quality of life and marital adjustment. Aim: The research`s purpose was to explore the effect
of Watson’s theory of human caring on women's coping way, quality of life and marital adjustment
after infertility treatment fails. Design: A quasi-experimental research design (one-group, time
series). Setting: In vitro fertilization unit that is affiliated to Benha university hospitals in Qalyubia
governorate. Sample: A purposive sample consisted of (46) infertile women with previous failed
IVF attempts and attended the above-mentioned setting for another IVF attempt; according to
established inclusion criteria. Tools: Four main tools were utilized for data gathering; a structured
interviewing questionnaire, stress coping styles inventory, quality of life questionnaire for infertile
women and revised dyadic marriage adjustment scale. Results: Statistical significant differences
were detected among mean scores of women’s coping way, quality of life, and marital adjustment
with (p- value < 0.001) at post intervention and follow up phases compared to pre intervention. Also, there
was a highly significant statistical positive correlation between total score of the studied women’s
coping way and total score of (infertility related quality of life and marital adjustment) and at preintervention, post-intervention and follow up phases (P ≤ 0.001).Conclusion: Nursing care based
on Watson's theory of human caring had a favorable outcome on women's coping way, quality of
life and marital adjustment especially after previous infertility treatment fails. Recommendation:
Incorporation of Watson's theory of human caring as a protocol in routine nursing intervention for
improving infertile women's coping way, quality of life and marital adjustment.