The black climbing rat, Rattus rattus, is considered one of the rat
species that spread in different Egyptian environments. It has great importance
in reducing the economic value of food and transmitting diseases. The toxicity
of four insecticides (Chlorzan 48% EC, Hachi Hachi 15% EC, Nasr
Lathion/Kemenova 57% EC, and Grab 2.5% EC) was tested at three different
concentrations (2.5, 5 and 10%) on changes in body weight, mortality rates,
and the effect on each of liver and kidney functions. As well as some
histological studies in R. rattus males. Results showed that Chlorzan 48%
recorded the highest effect during the various studies, as the percentage of
weekly body weight gain was the lowest (5.68 gm) after one-month posttreatment. The same insecticide also caused the highest rates of mortality,
reaching 40% at a concentration of 10%; on the other hand, ALT, AST, ALP
and urea rates were significantly increased, while the creatinine level
significantly decreased. Nasr Lathion/Cheminova 57% came in second place
in terms of its effect on R. rattus individuals. The toxicity of the two previous
insecticides was tested at a 5% concentration on histological changes in the
stomach, liver, heart and kidneys of R. rattus; there were clear histological
changes in the tissue sections examined as a result of treatment with these two
pesticides