The study aimed to determine the effect of nursing management protocol for dengue fever patients on their awareness, activities daily living and health outcomes. It was conducted at Qena Tropical Medicine Hospital.. Convenience samples comprised of 60 adult patients from both sex and were confirmed with dengue fever. Three instruments were used in this study. Tool 1: Basic data interview schedule it includes (socio-demographic data, medical history information and Patients' awareness assessment) Tool 2: Activity of daily living according to fever (The Barthel Index) Tool 3: it includes (patients' complaints assessment, vital signs assessment and laboratory investigations assessment .Nursing management protocol which include educational part and therapeutic clinical management(supportive care and fluid volume replacement) in addition to diet regimen Results/conclusion: The study findings revealed that mean ages for study and control group was 34.02 ± 10.77 and33.95 ± 10.48. According to knowledge assessment there was a significant difference between the study and control group pre and post implementation of the nursing protocol (P=