Background: Intraventricular hemorrhage (IVH) is a major neurological complication responsiblefor preterm neonates' morbidity and mortality. In the first 72 hours of life, nurses have a critical rolein maintaining bundled practices for intraventricular hemorrhage prevention. The study aimedtoassess preventive care bundle guidelines for nurses on the incidence of intraventricular hemorrhageamong preterm neonates who were mechanically ventilated. This study was carriedout at
Neonatal Intensive Care Unit of Specialized Pediatric Hospital at Benha city. Sample of thestudywas convenient sample for nurses and purposive sample for preterm neonates who consistedof 60preterm neonates on mechanical ventilation and 60 nurses who cared for themat previous setting. Tools of data collection included four tools, (1) A structured Interviewing Questionnaire Sheet, (2)Medical record of preterm neonates, (3) Intraventricular hemorrhage grading scale, (4) preventivecare bundle checklist. The main results of this study revealed high statistical significant
improvement in the studied nursesʹ total level of knowledge and total practice post- preventivecarebundle guidelines implementation. Additionally, there was a negative correlation betweentotal
nurses' knowledge, their practice and IVH incidence pre and post-neonatal care bundle guidelinesimplementation. The main recommendation is Conducting an orientation programs for nursesinNICU with regular updates of knowledge and practice regarding preventing intraventricularhemorrhage for enhancing the quality of care and reducing in the incidence of all grades of IVH.