Surgery is a therapeutic intervention that may have a threats to the integrity of human's body and soul. It can cause physiological and psychological responses for patients. The psychological response that may affect preoperative patients is anxiety which characterized by increased pulse and breathing frequency, uncontrolled hand movements, moist palms, restlessness, asking the same questions repeatedly, difficulty sleeping and frequent urination. The aim of the study was to evaluate the effect of alternate nostril breathing exercise on preoperative patients' anxiety, blood pressure and heart beats. Research design: Quasi- Experimental research design was utilized to achieve the aim of the study. Setting: This study was conducted in general surgery units for both males and females at Benha University Hospital