Objectives: To assess the value of sequential estimation
of biomarkers for prediction of gestation hypertension
(GHTN) and preeclampsia (PE) and to stratify PE
according to time of development and severity.
Patients & Methods: 80 normotensive (NT) newly
pregnant women who continued pregnancy and were free
of hypertensive manifestation (NT group), and the GHTN
group included 80 newly pregnant NT women who
developed high blood pressure (BP) measures without
proteinuria after the 20th gestational week (GW). Earlyonset PE (EO-PE) was diagnosed if a GHTN woman
developed proteinuria before the 34th GW, but after the
34th GW, it is Late-onset PE (LO-PE). PE was diagnosed
as mild if BP was