Background: Infants born to diabetic mothers face an increased risk
of hypoglycemia, necessitating reliable predictive markers for early
intervention. This study aimed to measure C-Peptide in umbilical
cord blood, to determine whether it can be used as a predictor of
hypoglycemia in infants of diabetic mothers. Methods: A total of 50
infants born to diabetic mothers were studied and they were divided
according to blood glucose levels into 25 experiencing hypoglycemia
and 25 remaining normoglycemic. Detailed histories, comprehensive
examinations, and multi-level investigations were conducted,
including C-peptide measurement from umbilical cord blood and
monitoring of glucose levels postnatally. Results: In the
hypoglycemic group, mean cord C-peptide levels were significantly
higher (5.2 ± 0.55 ng/ml) compared to the normoglycemic group
(1.71 ± 0.62 ng/ml). A significant negative correlation was found
between cord C-peptide levels and the blood glucose levels in the
early postnatal period. Additionally, a positive correlation existed
between cord C-peptide levels and birth weight. The sensitivity of
cord C-peptide in predicting hypoglycemia was 90%, with a
specificity of 88% and a cut-off value of 4.2. Conclusion: Cord Cpeptide levels in infants of diabetic mothers might be a predictive biomarker for hypoglycemia
in infant of diabetic mother.