Background: Diabetes mellitus is one of the most prevalent chronic childhood diseases, requiring ongoing
management to maintain optimal glycemic control and prevent complications. As primary caregivers, parents
play a critical role in their children's diabetes management; however, insufficient diabetes-related knowledge and
practices may compromise disease control and health outcomes. Nano-learning has emerged as an innovative
educational strategy with the potential to improve parental knowledge and practices related to diabetes care. Aim
of the study was to evaluate the effect of nano-learning strategy on knowledge and practices of parents regarding
diabetes mellitus. Study design: A quasi-experimental design (pre-posttest) was utilized. Setting: Pediatric
Diabetic Clinic in the Comprehensive Health Insurance Hospital (Hassan Awad Clinic), in Benha City, Qalyubia
Governorate, Egypt. Study subjects: A purposive sample of (50) parents of children recently diagnosed with
T1DM were gathered. Tools of data collection: Two tools were used; Tool I: A structured interviewing
questionnaire, Tool II: Parents-reported practices regarding DM. Results: Pre-nano-learning strategy
intervention, minority of parents reported satisfactory knowledge and practices. Furthermore, post and after onemonth of intervention, vast majority of parents demonstrated a satisfactory level of knowledge and practices.
Conclusion: The nano-learning strategy significantly improved parents’ knowledge and practices regarding
diabetes mellitus. It represents an effective and accessible educational approach for supporting parents in
managing their children's diabetes. Recommendations: Integrating nano-learning sessions into caregiver
education programs to enhance parents’ knowledge and practices in managing childhood diabetes.