Background: Complete mesocolic excision is defined as a surgical technique that comprises sharp dissection of the mesocolon’s visceral plane from the retroperitoneal plane without breaching of the visceral layer, which could lead to tumor cell spread within the peritoneal cavity. Heald et al, From Erlangen University first described complete mesocolic excision (CME) in conjunction with central vascular ligation (CVL) and demonstrated a correlation between anatomic and mesentery-based resection of right-sided colon cancer Patients and methods: This study includes a total of 40 patients with a diagnosis of Right Cancer Colon. By computer assisted randomization or card system our patients will be randomized into two groups: Group A: (20 patients) will undergo Open complete mesocolic right hemicolectomy and Group B: (20 patients) will undergo hand assisted laparoscopic complete mesocolic right hemicolectomy. The procedures occurred between 2021 and 2023. Results: The study showed no significant differences between the studied groups as regard all preoperative symptoms , preoperative lab findings, Stapler use , Method of dissection , blood loss , leakage , bleeding , infection and the pathological findings showed no significant differences as regard (prox. safety margin , distal safety margin , Harvested LNs , Positive LNs ). There were significant differences as regards type of anastomosis, operative time, time of reconstruction, time to pass first motion, time to start oral intake and hospital stay. Conclusion the laparoscopic approach has some advantages over the open approach regarding post-operative course and pathological outcome.