The focus of this review is on the synthetic routes available for different types of
pyrazoloquinoline derivatives. There are three types of synthetic methods: i) from pyrazole
derivatives; ii) from quinoline derivatives; and iii) miscellaneous methods. The position of
the linkage between pyrazole and quinoline rings determines the seven isomers of pyrazoloquinolines. The purpose of this review is to provide a guide for both synthetic and medicinal
chemists to discover and design new pyrazoloquinolines for medical purposes.