Fasciola gigantica is one of the worldwide parasites that cause livestock and human illnesses. Chemotherapy is now the
primary therapeutic option for its treatment. Drug abuse has led to the emergence of drug-resistant strains. As a result,
there is an urgent need to discover natural and efficient anthelmintics against Fasciola spp. The study aims to evaluate the
ovicidal activities of camel milk and its fractions on F. gigantica eggs. In the in vitro assay of F. gigantica eggs were submitted to different concentrations (0.5% and 1%) of camel milk fractions; Camel Milk Whey (CMW), Camel Milk Casein
(CMC), and Skimmed Camel Milk (SCM) as well as a positive control (PC) of Nitroxynil (100 mg/ml) and a negative
control (NC) with physiological saline. The Egg Hatching Assay (EHA) results showed that camel milk fractions exhibited
ovicidal activity, especially CMW, and CMC, which showed 97.58±0.58 and 96.9±1.99 ovicidal activity, respectively,
at a concentration of 1% after 15 days of treatment compared to PC, which exhibited 91.75±4.95 ovicidal activity. The
egg hatching ratios were 1.67% and 2.33% for CMW and CMC, respectively, compared to 70.17% for the NC and 6%
for the PC. The LC50 values for CMW and CMC on the 15th day of treatment were 0.20 and 9.13, respectively. From the
results above, we can infer that camel milk and its fractions are promising as a new alternative for fascioliasis control.