Objectives: The objective is to compare the new short protocol with traditional short protocol in ICSI programs.
Study design: Controlled trial.
Materials and methods: 40 cases scheduled for ICSI after a variable period of infertility classified into two
groups according to stimulation protocol. group1(20 case) with fixed 2 dose regimen (given merional ampoules) 4
ampoules first four days of stimulation the 3 ampoules thereafter while the other 20 patients given the traditional
short protocol starting with 3 ampoules then dose adjusted according to patient response.
Results: Days of stimulation, Number of merional ampoules, were significantly less in the new modified short
protocol than in the classic short protocol; while number of M2 oocytes, number of good embryos, pregnancy rate
were significantly high in the group 1. Pregnancy rate was 75% in the new modified protocol and 50% with the classic
short protocol.
Conclusion: The new short fixed 2 dose short protocol regimen offers a benefit in all the ways in ICSI success
and pregnancy rate with less time of gonadotropin stimulation and less cost.