Background: Chlorpyrifos (CPF), an organophosphorus
pesticide, negatively affects the thyroid gland, while avocado oil
possesses antioxidant properties that may offer protection. Aim:
The present study aimed to evaluate the protective role of
avocado oil against CPF-induced thyroid toxicity in adult male
albino rats. Methods: 40 adult male albino rats were randomly
divided into four groups (n = 10 each); the control group (G I)
received no treatment, the avocado-treated group (G II) received
avocado oil at 4 ml/kg body weight/day orally once daily for six
weeks, the CPF group (G III) was administered CPF at 6.7 mg/kg
body weight/day, dissolved in 4 ml/kg corn oil, orally once daily
for six weeks, and the avocado + CPF group (G IV) received
both avocado oil and CPF at the same doses and duration as G II
and G III. Results: CPF caused marked disruption of thyroid
histological
increased
architecture,
caspase-3
reduced PAS-positive reaction,
immuno-expression,
and
severe
ultrastructural alterations in follicular and parafollicular cells.
Co-administration of avocado oil with CPF largely restored
normal histological appearance, enhanced PAS reactivity,
decreased
caspase-3
immuno-expression, and improved
ultrastructural integrity of follicular and parafollicular cells.
Conclusion: Avocado oil exerts a potent protective effect against
CPF-induced
thyroid
histochemical,
damage,
mitigating
immunohistochemical,
alterations.