Introduction: As a cost-efficient and powerful pesticide, rodenticide, and fumigant, aluminium
phosphide (ALP) has been widely utilized. It can result in widespread suicide poisoning and high
mortality due to its ease of availability. ALP's active ingredient is phosphine (PH3). The human body
will suffer total damage as a result of exposure to PH3. Aim of work: The goal of the current study
was to examine the autopsy results from various human organs that had been poisoned with ALP in
the Medico-legal Department, Benha, Qalyubiyah, Egypt. Methodology: In this work, 10 control cases
and 10 chemically confirmed autopsy cases were included and examined in gross detail. Samples of
tissue from various organs were stained with hematoxylin-eosin and examined microscopically.
Results: This study includes a number of gross autopsy observations that have been made. Upon
concentrating on the pathological changes in the major organs, we discovered substantial PH3-induced
damage in many systems, particularly the stomach, duodenum, lung, and kidney. We also noticed
extensive myocardial, splenic, and hepatocellular deterioration in the heart, spleen, and liver tissues.
Conclusion: This study considered that these characteristic abnormalities were a possible indicator of
PH3 poisoning and partially explained the substance's deadly nature (inhibition of mitochondrial
oxidative phosphorylation) and that may contribute to a better understanding of PH3 toxicity in
both forensic and clinical conditions.