Background: Nursing care after brain surgery requires vigilant detailedpatients' monitoring and management to ensure neurological and systemic stability that enhancessafeand effective recovery. Study’ Aim: to evaluate effectiveness of post-operative nursingcareprotocol on nurses' performance and health outcomes among brain surgeries patients. Methods:The study used a quasi-experimental design specifically employing a pre/post-test thatconducted in the neurosurgical post-operative care units at Benha UniversityHospital.Convenience sample of 50 nurses and purposive sample of (66) adult patients were involvedin this study. Tools: (I) Nurses’ Self-Administered Questionnaire, (II) Nurses’ PracticeObservational checklist (III) Patient’ health outcomes assessment sheet. Results: only10.0%ofthe studied nurses had satisfactory level of knowledge pre nursing care protocol implementationcompared to 80.0% & 76.0% respectively at immediate and post three monthsofimplementation. As well as, only16.0% of the studied nurses had adequate level of practiceprenursing care protocol implementation compared to 82.0% &80.0%, respectively at immediateand post 3 months of implementation. In addition, there were statistically significant differencesbetween patient groups (pre/ post protocol implementation group) regarding severityofcomplications immediately post operative and on discharge than before. Conclusion: post-operative nursing care protocol effectively improved nurses’ knowledge, practices, andhealthoutcomes among brain surgery patients.