Both term and preterm infants are susceptible to pathological jaundice, a frequent condition that can cause long-lasting neurological damage. A novel treatment for indirect pathological hyperbilirubinemia is bilisphere phototherapy, which lowers
total serum bilirubin just as well as exchange transfusions. A quasi-experimental research design was utilized in the current
study. This study was conducted in Neonatal Intensive Care Unit at Benha Specialized Pediatric Hospital. A convenient
sample of all available nurses (60) working in the previously mentioned setting. A purposive sample of neonates (90) with
pathological jaundice which would be divided into control and study groups. Three tools were used: Tool I: A structured
interview questionnaire sheet, Tool II: observational checklist for caring neonates with pathological jaundice, and Tool III:
neonatal outcomes assessment sheet. There was a positive correlation between nurses’ total performance regarding pathological jaundice and bilisphere phototherapy at pre-/post-education program implementation. Additionally, there were a positive
correlation between neonates’ outcomes in the study group and nurses’ total performance post-program implementation.
Conclusion the education program regarding pathological jaundice was efective in improving nurses’ performance and
neonates’ bilirubin-induced neurological dysfunction post compared to pre-education program implementation.