Background: Increased glycolysis has been considered one of the characteristic features of cancer.Glucose transporter 1 (GLUT1) plays a central role in the transport of glucose in tumor cells. CD147 is multifunctional glycoprotein overexpressed in many solids tumors.
Methods: This is a retrospective controlled study on 46 cases of prostatic carcinoma to recognize the expression of GLUT1 and CD147 by immunohistochemistry and to identify their correlation with different clinicopathological parameters.
Results: GLUT1 and CD147 positive expression was detected in 25/46 (54.3%) and 29/46 (63.0%) of prostatic carcinoma, respectively. GLUT1 and CD147 expression was significantly higher in prostatic carcinoma than BPH and HGPIN. Significant positive correlation between GLUT1 and CD147 immunoreactivity in prostatic carcinoma was seen. Positive GLUT1 expression was statistically correlated with high Gleason score (P