امنية يوسف بسيونى
أستاذ
Significance of Stathmin1 and Acetyl-CoA Synthetase 2 Expression and Morphometric Analysis in Colorectal Carcinoma and Precancerous Lesions
Benha medical journal. • 2025
معلومات البحث
المؤلفون
Hadeer M. Elshahat, Ahlam A. Abd El-maksoud, Magdy M. Nouh,
Omneya Y.Bassyoni
الكلمات المفتاحية
premalignant lesions or precancerous lesions,
colorectal carcinoma, STMN1, ACeCS2 immunohistochemistry
المجلة العلمية
Benha medical journal.
الناشر
Benha University, Faculty of Medicine
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
Local
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Background: Colorectal cancer (CRC) is the third leading cause
of cancer death in the world. Precancerous lesions that may
progress to CRC include inflammatory bowel disease (IBD) and
adenoma This study aims to clarify the role of STMN1 and
ACeCS2 and the morphometric changes in colorectal
carcinogenesis. Material and methods: This is a retrospective
study on 100 cases; control (n=8) IBD (n=29), convetional
adenoma (n=19), serrated polyp/adenoma (n=9) and CRC
(n=35), All cases were stained with STMN1 and ACeCS2
antibodies using Avidin-biotin complex. In morphometry, we
assessed nuclear morphometric parameters and gland/stromal
ratio among studied groups. Results: There was statistically
significant correlation between Stathmin-1 and dysplasia in IBD
(p=0.008), with dysplasia (p=0.05), types (p-0.003) of
conventional adenoma, staging (p=0.015) and node metastasis
(p=0.04) of CRC cases. There was statistically significant
correlation between ACeCS2 among studied groups (p=0.006),
with dysplasia in IBD (p=0.002), staging (p=0.001) and node
metastasis (p=0.004) of CRC. There was statistically significant
correlation between morphometric parameters among studied
groups (P
of cancer death in the world. Precancerous lesions that may
progress to CRC include inflammatory bowel disease (IBD) and
adenoma This study aims to clarify the role of STMN1 and
ACeCS2 and the morphometric changes in colorectal
carcinogenesis. Material and methods: This is a retrospective
study on 100 cases; control (n=8) IBD (n=29), convetional
adenoma (n=19), serrated polyp/adenoma (n=9) and CRC
(n=35), All cases were stained with STMN1 and ACeCS2
antibodies using Avidin-biotin complex. In morphometry, we
assessed nuclear morphometric parameters and gland/stromal
ratio among studied groups. Results: There was statistically
significant correlation between Stathmin-1 and dysplasia in IBD
(p=0.008), with dysplasia (p=0.05), types (p-0.003) of
conventional adenoma, staging (p=0.015) and node metastasis
(p=0.04) of CRC cases. There was statistically significant
correlation between ACeCS2 among studied groups (p=0.006),
with dysplasia in IBD (p=0.002), staging (p=0.001) and node
metastasis (p=0.004) of CRC. There was statistically significant
correlation between morphometric parameters among studied
groups (P