Background: Diabetes mellitus (DM) is strongly associated with
chronic hepatitis C virus (HCV) infection. This work aimed to estimate
the impact of Hepatitis C virus infection on glycaemic state and insulin
resistance in type 2 Diabetic patients, and evaluate the effect of directacting oral antiviral treatment on the glycaemic state and insulin
resistance in type 2 Diabetic patients. Methods: The study was
performed on (40 patients) with Type 2 Diabetes who were infected by
Hepatitis C Virus and took Direct-acting Oral Antiviral Drugs. The
study also included (10 patients) who had Type 2 Diabetes and HCV
infection serving as control group. All patients and control were
subjected to thorough history taking, clinical examination, and lab.
investigations as FBG, PP and HBA1c , Serum fasting Insulin level,
And HOMA-IR, HCVAb – HBsAg – HIVAb, CBC, SGOT, SGPT,
Serum Albumin and Bilirubin, PCR for HCV RNA, and Abdominal
US. Results: DAAs-based eradication of HCV is associated with
improved glycemic control in patients with type 2 diabetes as evidenced by a significant reduction
of mean FBG, Fasting insulin, HbA1c, and HOMA IR. There was a positive correlation between
the treatment of HCV infection and the reduction of anti-diabetic drugs used in the studied
patients. Conclusion: DAAs-based eradication of HCV is associated with improved glycemic
control in patients with type 2 diabetes.