Background: Colorectal carcinoma (CRC) is the third most common
cancer in the world. The chemokine CXCL9 is a small molecule
belongs to (CXC family) which secreted by (IFN-γ) stimulated
macrophages. VEGF-α plays central role in the regulation of
angiogenesis and lymphangiogenesis. Aim : This work aimed to
evaluate the role of CXCL9 and VEGF α in colorectal
adenocarcinoma. Material and method: This retrospective study was
carried upon 50 cases of colorectal adenocarcinoma. CXCL9 and
VEGFα immunostaining was done and assessed for each case. Results:
There was an insignificant statistical correlation between both CXCL9
and VEGF -α expression and patient`s age, sex, tumor size and site (P
value >0.05). But there was a highly significant inverse statistical
correlation between CXCL9 expression and tumor grade, depth of
tumor invasion, lymph node metastasis, distant metastasis
lymphovascular invasion and tumor stage (P value