رضا ابراهيم احمد الكمار
أستاذ مساعد
Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine.
Environmental Science and Pollution Research • 2022
معلومات البحث
المؤلفون
Asmaa Elsayed; Ashraf Elkomy; Mohamed Alkafafy; Reda Elkammar; Anwar El‑Shafey; Ahmed Soliman; Mohamed Aboubakr.
الكلمات المفتاحية
Cisplatin · N-acetylcysteine · Lycopene · Oxidative stress · Testosterone · Testes
المجلة العلمية
Environmental Science and Pollution Research
الناشر
Not Available
المجلد
29
العدد
Not Available
الصفحات
24077–24084
publication.type
International
رابط البحث
Open Link
المواد المرفقة
Not Available
الملخص
Lycopene (LP) and N-acetylcysteine (NAC) protective effects were assessed for testicular toxicity mediated by cisplatin
(CP) in rats. Forty-nine rats were divided into 7 groups (n = 7); these groups included the control group (saline, PO), LP (10
mg/kg, PO), NAC (150 mg/kg, PO), CP (7.5 mg/kg, IP) on the 27th day of the study, LP + CP, NAC+CP, and LP + NAC +
CP. Serum levels of testosterone were decreased following CP injection. Malondialdehyde (MDA) has been increased with
considerable glutathione (GSH), and dismutase superoxide (SOD) and catalase (CAT) decline in the testis tissues after CP
injection. CP caused severe alterations in testicular tissues and elevated caspase-3 expression. Besides that, LP and/or NAC
administration improved CP-induced testicular toxicity and apoptosis, probably via their antioxidant properties.
(CP) in rats. Forty-nine rats were divided into 7 groups (n = 7); these groups included the control group (saline, PO), LP (10
mg/kg, PO), NAC (150 mg/kg, PO), CP (7.5 mg/kg, IP) on the 27th day of the study, LP + CP, NAC+CP, and LP + NAC +
CP. Serum levels of testosterone were decreased following CP injection. Malondialdehyde (MDA) has been increased with
considerable glutathione (GSH), and dismutase superoxide (SOD) and catalase (CAT) decline in the testis tissues after CP
injection. CP caused severe alterations in testicular tissues and elevated caspase-3 expression. Besides that, LP and/or NAC
administration improved CP-induced testicular toxicity and apoptosis, probably via their antioxidant properties.