رحاب محمد سالم عروه
أستاذ
Could α MSH-MIFT Axis and IDH2 be Considered Promising Predictors of Non-segmental Vitiligo Response to NB-UVB Phototherapy?
• 2023
معلومات البحث
المؤلفون
KHALED MOHEY EL DIN MONIB, MD; NEVEEN EMAD SOROUR, MD; NAGLAA FATHY ALHUSSEINI, MD;
ASMAA GABER ABDOU, MD; AMAL YOUSIF, MD; and REHAB MOHAMMED SALEM
الكلمات المفتاحية
Not Available
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
The search for objective factors that help in predicting the response of vitiligo treatment is very important. OBJECTIVE:
We sought to evaluate the e ect of NB-UVB phototherapy on both the alpha melanocyte stimulating hormone-microphthalmia-associated
transcription factor (α-MSH-MIFT) axis, and isocitrate dehydrogenase 2 (IDH2) in non-segmental vitiligo (NSV). METHODS: This prospective
clinical trial included 50 NSV patients and 50 healthy control subjects. α-MSH tissue levels as well as MITF and IDH2 immunostaining were
assessed in normal and vitiliginous skin biopsies before treatment and then in the repigmented areas following 24 NB-UVB phototherapy
treatment sessions using ELISA technique and immunohistochemical study, respectively. RESULTS: There was a signi cant negative correlation
between baseline VASI scores and the tissue levels of α-MSH (p=0.006) and the expression of both MITF (p
We sought to evaluate the e ect of NB-UVB phototherapy on both the alpha melanocyte stimulating hormone-microphthalmia-associated
transcription factor (α-MSH-MIFT) axis, and isocitrate dehydrogenase 2 (IDH2) in non-segmental vitiligo (NSV). METHODS: This prospective
clinical trial included 50 NSV patients and 50 healthy control subjects. α-MSH tissue levels as well as MITF and IDH2 immunostaining were
assessed in normal and vitiliginous skin biopsies before treatment and then in the repigmented areas following 24 NB-UVB phototherapy
treatment sessions using ELISA technique and immunohistochemical study, respectively. RESULTS: There was a signi cant negative correlation
between baseline VASI scores and the tissue levels of α-MSH (p=0.006) and the expression of both MITF (p