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أستاذ مساعد
Theameliorativeimpactsofwheatgermoilagainstethanol-inducedgastriculcers:involvementofanti-inflammatory,antiapoptotic,andantioxidantactivities
• 2023
معلومات البحث
المؤلفون
RababShabanEl-shafey1,SamarH.Baloza2,LinaAbdelhadyMohammed3,HendElsayedNasr3,MohamedMohamedSoliman4,*,HebaI.Ghamry5,SalwaA.Elgendy6
الكلمات المفتاحية
Not Available
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
Local
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Thisstudyexaminedifwheatgermoil(WGO)hasgastroprotectiveimpactsagainstethanol-inducedgastriculcerinrats.Ratswereassignedintocontrol,WGO,ethanol,omeprazole+ethanol,andWGO+ethanol.WGOpreventedgastriculcerationanddamageinducedbyethanol,thesameeffectinducedbyomeprazole,awidelyknownmedicationusedforgastriculcertreatment.WGOreducedgastriculcerindex,nitricoxide,andmalondialdehydelevelsinthestomach.WGOboostedtheexpressionofnuclearfactorerythroid2-relatedfactor2(Nrf2),hemeoxygenase-1(HO-1),Bcl2,andtheantioxidants.WGOshowedinflammatoryandanti-inflammatoryimpactsthroughthecontrolofinterleukin(IL)-1β,Tumornecrosisfactoralpha(TNF-α),andIL-10thatwerealteredinethanol-administeredrats.Ethanolup-regulatedcaspase-3andnuclearfactor-kappaB(NF-kB)expressionandshowedhistopathologicalchangessuchasnecrosisandmucosaldegenerationthatweremitigatedbypre-administrationofWGO.Moreover,WGOdecreasedgastricimmunoreactivityofNF-kBandincreasedtransforminggrowthfactorbeta-1(TGF-β1)thatwereassociatedwithupregulationofNrf2,hemeoxygenase-1(HO-1),andantioxidantexpressionandproduction.Inconclusion,WGOreducedethanol-inducedstomachtoxicitybyregulatinggenesinvolvedinoxidativestress,inflammation,andapoptotic/antiapoptoticpathways.