Phytase is crucial in enhancing the bioavailability and release of phosphorus and
other nutrients bound to phytic acid, making them more bioavailable for animal
absorption. This study was carried out to inspect the effect of supplementing low
phosphorus (P) diet with di‐calcium phosphate (DCP) and liquid phytase enzyme (LP),
which contains 1500 FTU/kg, on growth performance, intestinal morphometry,
proximate body chemical composition, blood profile, immunity status, liver
mitochondrial enzyme activities, the expression response and economic returns of
Nile tilapia (Oreochromis niloticus). Three triplicate groups of fish (initial weight
5.405 ± 0.045 g, N = 90) were fed on three different diets for 90 days. The first was a
control diet with zero DCP; the second was a control diet supplemented with 0.71%
DCP; the third was a control diet supplemented with 0.03% LP. The groups were
designated as CG, DCP and LP, respectively. Results showed that LP induced
considerable improvements (p < 0.05) in FBW, body weight gain, weight gain rate,
specific growth rate, HIS, viscero‐somatic index, spleen‐somatic index