Background: The autoimmune disease multiple sclerosis (MS) typically strikes middle-aged and younger adults. Genetic biomarkers linked to multiple sclerosis include single nucleotide polymorphisms (SNPs). Aim of the work: aim of the work guided to study the role of IL17A genetic variant (rs 2275913) and its association with reduced risk of MS disease in Egyptian patients. Subjects & Methods: This cross-sectional study included 50 participants; 30 patients diagnosed with MS attended MS Unit of Department of Neuropsychiatry and outpatient clinic of Benha University Hospitals and 20 apparently healthy control candidates. This study aimed to determine whether there is a correlation between the IL17A gene variation rs2275913 A/G and the MS risk. Genetic material were extracted from EDTA blood and genotyping was carried out using the PCR-RFLP method for rs2275913. Then, we looked at how the frequency of different genotypes and alleles correlated with disease risk.