سامية محمود مناوي ابراهيم
أستاذ
Moringaoleiferaleavesethanolicextractcounteractscorticalneurodegenerationinducedbyaluminumchlorideinrats
• 2024
معلومات البحث
المؤلفون
RababFawzyHindawy
1
,
SamiaM.Manawy
2
,
OlaElsayedNafea
3,*
,
AbeerA.Abdelhameed
4
,
FatmaFawziHendawi
4
الكلمات المفتاحية
Not Available
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
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الصفحات
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publication.type
Local
رابط البحث
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المواد المرفقة
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الملخص
Dementiaisacognitivedysfunctionthatdisruptsday-to-dayactivitiesandsocialfunctions.Theunderlyingetiologiesofdementiaarenumerousincluding,butnotlimitedto,primaryneurologic,neuropsychiatricaswellasassociationswithmedicaldisorders.Alzheimer’sdisease(AD)isthemostprevailingtypeofdementiaandrepresentsasignificanthealthcareburden,asso-ciatedwithconsiderabledisabilityandmortalityworldwide.1–6Recentevidencesuggestsalinkbetweenthedevelopmentofneurodegenerativedisordersandexposuretoenvironmentaltoxins.7
AluminumisawidelyabundantelementintheEarth’scrust.Inthepresentcenturyitisoftenreferredtoasthe“aluminumage”duetoitsextensiveuseinseveraldailylifeactivities.Forinstance,itisusedasavaccineadjuvant,inantacids,cookingwares,cosmetics,foodadditives,andskincareproducts.However,itcanbefoundasacontaminantinmanyfoodproducts,includinginfantformula,juice,milkproducts,seafood,tea,andwine.
Inaddition,environmentalsourcesofaluminumexposureincludedrinkingwaterresultingfromwatertreatmentprocesses,aswellasnaturaloccurrencesthroughtheweatheringofrocksandsoils,orpollution-inducedacidrains.Aluminumpossessesexcellentphysicalandchemicalproperties;thus,aluminumisextensivelyusedinawiderangeofindustrialapplications.Consequently,theabundanceofaluminum,coupledwithitsextensivehumanuse,putsindividualsatasignificantriskofaluminumtoxicity.Aluminumisawell-recognizedneurotoxinthatcandisrupttheblood–brainbarrierandaccumulateinhighconcentrationsinbraintissuesandithasbeenimplicatedinvariousneurodegenerativedisorders.TheassociationbetweenthedevelopmentofADandlowaluminumdosesremainsamatterofdebate.ADhasamultifactorialetiologyandextremelyvariablepresentation.8–12
Aluminumexposurehasbeenshowntocauseneuronaldam-agethatmimicstheclinicalmanifestationsandpathologicaleventsthatareobservedinAD.TheinitialanddominantfindinginthepathogenesisofADisamyloid-βproteindepositioninthebrain,othercontributingfactorsincludedysregulatedneu-rotransmitters,metaldeposition,neuronaloxidativestress,neu-roinflammation,mitochondrialdysfunction,andcholinergicneu-ronsdegeneration.13–17
Currenttreatmentapproachesforneurodegenerativedisordershavelimitationsandoftenresultinunsatisfactoryclinicaloutcomes.18,19Naturalphytochemicals
AluminumisawidelyabundantelementintheEarth’scrust.Inthepresentcenturyitisoftenreferredtoasthe“aluminumage”duetoitsextensiveuseinseveraldailylifeactivities.Forinstance,itisusedasavaccineadjuvant,inantacids,cookingwares,cosmetics,foodadditives,andskincareproducts.However,itcanbefoundasacontaminantinmanyfoodproducts,includinginfantformula,juice,milkproducts,seafood,tea,andwine.
Inaddition,environmentalsourcesofaluminumexposureincludedrinkingwaterresultingfromwatertreatmentprocesses,aswellasnaturaloccurrencesthroughtheweatheringofrocksandsoils,orpollution-inducedacidrains.Aluminumpossessesexcellentphysicalandchemicalproperties;thus,aluminumisextensivelyusedinawiderangeofindustrialapplications.Consequently,theabundanceofaluminum,coupledwithitsextensivehumanuse,putsindividualsatasignificantriskofaluminumtoxicity.Aluminumisawell-recognizedneurotoxinthatcandisrupttheblood–brainbarrierandaccumulateinhighconcentrationsinbraintissuesandithasbeenimplicatedinvariousneurodegenerativedisorders.TheassociationbetweenthedevelopmentofADandlowaluminumdosesremainsamatterofdebate.ADhasamultifactorialetiologyandextremelyvariablepresentation.8–12
Aluminumexposurehasbeenshowntocauseneuronaldam-agethatmimicstheclinicalmanifestationsandpathologicaleventsthatareobservedinAD.TheinitialanddominantfindinginthepathogenesisofADisamyloid-βproteindepositioninthebrain,othercontributingfactorsincludedysregulatedneu-rotransmitters,metaldeposition,neuronaloxidativestress,neu-roinflammation,mitochondrialdysfunction,andcholinergicneu-ronsdegeneration.13–17
Currenttreatmentapproachesforneurodegenerativedisordershavelimitationsandoftenresultinunsatisfactoryclinicaloutcomes.18,19Naturalphytochemicals